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Summary of Erythrose Beat Cancer

If you graduate from high school you can understand this. 

Erythrose (C4H8O4) is a sugar, 2/3 of glucose (C6H12O6).

Not only erythrose has similar structure as glucose, but also it can be used for respiration as glucose, to be converted to CO2 and H2O (Batt et al. 1960).

Erythrose-4-phosphate is in our body. (participates in Pentose Phosphate Pathway)

Low toxicity: Erythrose’s mirror, erythrulose, toxicity is very low (NICNAS, Australia 2008).

Cancer cell lines (lung, brain, breast, etc) die with ~4mM erythrose in 24hrs.

Blood glucose reaches ~8 mM after meal, people with diabetes can tolerate 30mM for days.

For normal cell lines viability, up to 30mM erythrose, it has similar result as glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have been tested.

Erythrose is very similar to glucose for our cells, but kills cancer. Energy is essential for all cells in our body. Technology can deliver the 4mM erythrose to anywhere in our body. Cancer will be destroyed. The side effects could be as short-term diabetes, manageable and reversible

Although erythrose is a sugar and existed in our body. Before proper testing, it should not be used to treat people. It could be either miss the threshold or very dangerous without proper administration. The only credit supplier is Sigma, $400/g, our body can digest sugar very fast. No one can afford it now.

The solution is very simple to understand. High school education is enough to understand. You just need common sense and logical think to understand that this is the only way we can beat cancer and save life. 

In general, it costs $1 billion to develop a drug. Life is priceless. Unfortunately, there is price tag. The only way to save us is by us. I have done whatever I can.

Scam Alert: If some one tries to sell you erythrose as self-administrated medicine, it is a scam. Please do not spent any money on it. Based on the biology of how erythrose works and the biochemistry, it will not be a help-yourself medicine. It needs professional training to avoid causing damage to your body. Also it is sugar, your body will digest it very fast.


What is Cancer? According to National Cancer Institutes: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues.

Cell’s Life: cells >> divide >> differentiate to functional cell >> die.

Cancer cells are our cells of our body. Cancer is a disease of undifferentiated dividing cells. Make cancer cell differentiate. Cancer is stopped!!!

How Cell Survive? (http://hyperphysics.phy-astr.gsu.edu/hbase/biology/celres.html)

 

All cells of our body need energy to survive. There are two major energy processes, respiration and fermentation. Most cells in our body have the abilities of both fermentation and respiration. Glucose is major universal fuel of our body. In respiration, with oxygen participation, glucose is converted to carbon dioxide and water. In fermentation, without oxygen participation, glucose is converted to lactate.

What is the difference between normal cell and cancer cell?  (Heiden, et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science 324, 1029 (2009))

Since 1920’s, eighty years ago, people have known that normal cells (differentiated cells) mainly depend on respiration, while cancer cells mainly depend on fermentation. Not all cells mainly depending on fermentation divide. But all cells mainly depending on respiration do not divide.

There are many and various reasons of cancer, genes, pathways, etc. The most profound, obvious, and significant difference is that differentiated cells (normal cells) mainly depend on respiration; while cancer cells mainly depend on fermentation. Dr. Warburg first reported this in 1920's. Not all cells, mainly powered by fermentation, divide. All cells, mainly powered by respiration, do not divide. Increasing cancer cell respiration will stop cancer cell dividing.

How to increase cell respiration?

Increasing mitochondria respiration. In human cell, respiration is in mitochondria. Mitochondria respiration is suppressed when cells divide (cancer cell and other dividing cells). Cell division could be the reason of mitochondria suppression. Cells have adapt this since the beginning of the cell.

Increasing non-mitochondria respiration. Aerobic bacteria without mitochondria have non-mitochondria respiration ability. Cancer cell has high oxidative stress, which has advantage to use non-mitochondrial respiration. Giving proper substances of respiration to cancer cell, cancer cell will be destroyed.

What does cancer like? Because cancer mainly depends on fermentation, cancer cells take more sugar than normal cell. Cancer likes sugar. PET Scan is based on this. What will happen if we give cancer a sugar, cancer has to use it for respiration?  The sugar is erythrose. Erythrose beats cancer.

What is Erythrose?


  1. Erythrose is a sugar, has 2/3 weight and similar structure of glucose.
  2. Erythrose is used for respiration. Feed rat radioactive erythrose, the radioactivity appears in respiratory carbon dioxide, in glucose or liver glycogen, and in urinary excretion (Batt et al. 1960). The final products are carbon dioxide and water.
  3. Erythrose-4-phosphate is in our body, participates in Pentose Phosphate Pathway
  4. Low toxicity. In human health effects assessment with erythrulose, an isomer of erythrose, in rat, acute oral LD50 >2 g/kg bw, low toxicity; rat, repeat dose oral toxicity – 28 days, No Observed Effect Level (NOEL) is 1g/kg bw/day. It is non mutagenic to bacterial reverse mutation (NICNAS Australia, 2008).

Cell Culture with Erythrose
Cancer cell lines (lung, brain, breast, etc.) die with ~4mM (500mg/L) erythrose in 24 hrs.
For normal cell lines viability, up to 30mM erythrose, it has similar result as glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have been tested.



Erythrose is very similar to glucose for our cells, but kills cancer. Energy is essential for all cells in our body. Technology can deliver the 4mM erythrose to anywhere in our body. Cancer will be destroyed. The side effects could be as short-term diabetes, manageable and reversible.
Cancer cells die with enough erythrose, the concentration is well below similar small molecules our body can tolerate. Using Erythrose treat cancer is doable, and will be workable.
Cancer, undifferentiated dividing cells, lack of respiration by complex genetic and biochemical reasons. Cancer cells have to use Erythrose for respiration to differentiate, and die. Erythrose beats cancer.

Cells in our body obtain energy to survive through respiration (oxidation) and fermentation. Respiration yields CO2 and water. Fermentation yields lactate. In 1920s’ Dr. Otto Warburg found that cancer cells thrive through fermentation mainly. Modern science also proves that cancer cell depends on fermentation. Most cells have the function of both, respiration and fermentation. Cancer cells are flawed or damaged. It will die if we can switch its fermentation to respiration. How can we switch it? Magic pill, not exists yet. Respiration mainly occurs in mitochondria. Fermentation occurs in cytosol. Mitochondria are dysfunction in most of cancer cells. Mitochondria are controlled by genetic code from both mitochondria and nucleus. Switch on mitochondria respiration of cancer may not be possible since cancer is formed in very long time. What we can do? Organisms have cytosolic respiration ability. Increase Cytosolic Respiration will initiate cell differentiation of dividing cell. Flawed or damaged cancer cell will die when respiration is increased and differentiation is initialized. How can we induce cancer cytosolic respiration? Give what cancer likes. Cancer likes sugar, in fact, glucose, the universal fuel of our body, is one of the causes of cancer. Sweet for cancer! What about other sugars, which must be used in cytosolic respiration. It is the tetrose, a sugar with 4 carbon atom. Candy for cancer:)?!

In short, with the supports of my families and friends, we have conducted our experiments with British Columbia Preclinical Research Consortium, StemCell Technologies, and 2 laboratories in China. Some results were presented at American Association for Cancer Research 101 Annual Meeting, "Erythrose Kill Cancer Cell in vitro and Inhibit Tumor Growth in vivo".  http://www.abstractsonline.com/plan/ViewAbstrac...  (For cell line experiment using TryPan Blue Assay, the original method, to measure cell death. Several other modern assays are interrupted by erythrose).

LILI LIU, TAO YI and XIA ZHAO 2015. Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma ONCOLOGY LETTERS 9: 769-773, 2015.  http://www.spandidos-publications.com/ol/9/2/769

Here is the evidence of erythrose and cancer:

Erythrose (C4H8O4) is a sugar, 2/3 of glucose (C6H12O6).

Not only erythrose has similar structure as glucose, but it can be used for respiration as glucose in rats, to be converted to CO2 and H2O (Batt et al. 1960).

Erythrose-4-phosphate is in our body, participates in Pentose Phosphate Pathway.

Low toxicity: Erythrose’s mirror, erythrulose, a tetrose, toxicity is very low (NICNAS, Australia 2008).

Cancer cell lines (lung, brain, breast, etc) die with ~4mM erythrose within 24hrs.

Blood glucose reaches ~8 mM after a meal. People with diabetes can tolerate 30mM for days. Plasma Ketones (4 carbon compound) rises to 15mM during fast. Lactate (3 carbon compound) can reach 4mM after exercise.

For normal cell lines viability, up to 30mM erythrose/glucose, has similar result. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have been tested.

Sugar metabolism is same in cell lines or in mammals. Erythrose Kills Cancer in cell lines, the condition can be replicated to human organ. As long as we provide cancer with this condition, cancer will die. Since Erythrose is a sugar, could be used for respiration, it will have little or no side effect.

Erythrose is very similar to glucose for our cells, but kills cancer. Energy is essential for all cells in our body. Technology can deliver the 4mM erythrose to anywhere in our body. Cancer will be destroyed. The side effects could be as short-term diabetes, manageable and reversible

Why Human Lose the Battle?

What is Cancer? 1). Cancer is not an intruder. Cancer cells have >99% same genes as non-cancer cells. 2). Cell Life Path - cells go through division, differentiation, function, aging, and dying. 3). Stem cells differentiate into specialized cells, such as skin, blood cell, etc. --> Differentiation. 4). The difference of cancer from non-cancer cells is continuous dividing, but not differentiating. 5). Inducing or forcing cancer cell to differentiate will defeat cancer. 

Why Cancer Divide? 1).There are only two reasons for cell dividing, Growth and Repair. Cell divide, then, differentiate to accomplish Growth and Repair.Only non-specialized cells (stem cell) can divide. Specialized cells (red blood cell, etc.) do not divide. 2). Since cancer cell is damaged and flawed, it divides, but not differentiates. Growth or Repair is not fulfilled. 3). The worse, dividing cancer cells produce large amount of lactic acid and cause further and more damage to adjacent normal cells. More repair is required, which stimulates more dividing. 4). Cancer cells hijack the processes of growth and repair. Cancer depends on fermentation. Forcing cancer cells to respire will stop cancer divide and enter death path. 

LOSS by Fighting Ourselves 1). Cancer cells have >99.99% same genome as non-cancer cells. Fighting = Destroy. 2). Current Chemo Treatments:Cell Division or DNA Targeted - Kill all dividing cells, damage whole body.  Cell division is essential for repair and renew. Cancer Biochemical Pathway Targeted - Cell biochemistry is a very complicated web. Many pathways work together, substitute each other. Block one, others fill in. This also explains that cancer can be caused by many different genome mutations. There are many reasons, but one result - continuous dividing.

The Only Way To Defeat Cancer. A Simple Switch of Life.

1). Our body depends on Glucose, can use Erythrose for energy. Our cells obtain energy from Respiration and Fermentation. 2). Cancer cells are damaged and flawed, depend on fermentation to continuously divide, could not differentiate to be useful specialized cells. Increase respiration will stop dividing and induce cancer death. 3). Glucose can be used for respiration and fermentation for normal cells, but can only be used for fermentation by cancer cell. Erythrose has to be used for respiration, cancer cell will differentiate, cancer cell dividing is stopped and cancer death is induced.

For further information, please google Erythrose and Cancer. I have some information on the internet, such as www.meke.com. If you still have questions, you can email me at xingnongwang@gmail.com or add comment on youtube (https://www.youtube.com/watch?v=voxsK9MtHcU) and notice me. I will answer asap.

Thank You and Best Regards.

Xingnong Wang

Reference:

1.Warburg, O., Biochem. Z., 1923, cxlii, 317.

2.Warburg, O., Posener, K., and Negelein, E., Biochem. Z., 1924, clii, 309.

3.Negelein, E., Biochem. Z., 1925, clviii, 121; 1925, clx, 307.

4.OTTO WARBURG, FRANZ WIND, AND ERWI'N NEGELEIN 1926 THE METABOLISM OF TUMORS IN THE BODY)

5.Warburg O (1930) Metabolism of Tumors. Arnold Constable, London, UK.

6.Warburg O (1956) On the origin of cancer cell. Science 123: 309–314.

7.Mazurek S, Boschek CB, Eigenbrodt E (1997) The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy. J Bioenerg Biomembr 29, pp. 315–330.

8.Ristow M (2006) Oxidative metabolism in cancer growth. Curr Opin Clin Nutr Metab Care (4): 339–345.

9.Putignani L, Raffa S, Pescosolido R, Aimati L, Signore F, Torrisi MR, Grammatico P (2008) Alteration of expression levels of the oxidative phosphorylation system (OXPHOS) in breast cancer cell mitochondria. Breast Cancer Res Treat 110(3): 439-452.

10.Heiden, et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science 324, 1029 (2009). 

11.Batt RD, Dickens F, Williamson DH. 1960. Tetrose metabolism 2. The utilization of tetroses and tetritols by rat tissues. Biochem J. 77:281-94.

12.Hiatt HH, Horecker BL. 1956. D-erythrose metabolism in a strain of Alcaligenes faecalis. J Bacteriol. 71(6):649-54.

13.National Industrial Chemicals Notification and Assessment Scheme (NICNAS). Erythrulose. Australia February 11, 2008.

14.Wang X and Wei Y 2010 “Erythrose kill cancer cell in vitro and inhibit tumor growth in vivo” American Association for Cancer Research 101th Conference.

15. LILI LIU, TAO YI and XIA ZHAO 2015. Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma ONCOLOGY LETTERS 9: 769-773, 2015.